Staff Reporter :
A major non-profit health emergencies group has set up a global laboratory network to assess data from potential Covid-19 vaccines, allowing scientists and drugmakers to compare them and speed up selection of the most effective shots, Reuters reported.
Speaking to Reuters ahead of announcing the
labs involved, Melanie Saville, director of vaccine R&D at the Coalition for Epidemic Preparedness Innovations (CEPI), said the idea was to “compare apples with apples” as drugmakers race to develop an effective shot to help control the Covid-19 pandemic.
The centralised network is the first of its kind to be set up in response to a pandemic, CEPI said in a media release.
The CEPI network will initially involve six labs, one each in Canada, Britain, Italy, the Netherlands, Bangladesh and India, Saville said.
The laboratories initially selected for this vaccine-assessment network are: Nexelis in Canada; Public Health England in the UK; VisMederi Srl in Italy; Viroclinics-DDL in the Netherlands; International Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b) in Bangladesh; and Translational Health Sciences and Technological Institute in India.
“Ensuring that immunological responses to Covid-19 vaccines are measured systematically in a manner that allows valid comparisons of vaccines will be essential to global efforts to identify those vaccines of greatest public health value,” said Professor John D Clemens, MD and Executive Director at icddr,b.
“We commend CEPI’s efforts to establish a centralised laboratory network, and, as an organisation with decades of experience in evaluating vaccines, we are keen to contribute to the network,” Prof Clemens added.
The network will use the same testing reagents-originating in the labs of Nexelis and PHE-and follow common protocols to measure the immunogenicity of multiple Covid-19 vaccine candidates including both CEPI-funded and non-CEPI funded developers, the CEPI release read.
This approach will ensure uniformity in assessment and informed identification of the most promising vaccine candidates, it also read, adding that CEPI is actively negotiating with additional laboratories to participate in this network.
In the network spanning Europe, Asia and North America, the labs will centralise analysis of samples from trials of Covid-19 candidates “as though vaccines are all being tested under one roof”, Saville said, aiming to minimise the risk of variation in results.
“When you start off (with developing potential new vaccines) especially with a new disease, everyone develops their own assays, they all use different protocols and different reagents – so while you get a readout, the ability to compare between different candidates is very difficult,” she told Reuters.
“By taking the centralised lab approach … it will give us a chance to really make sure we are comparing apples with apples.”
Hundreds of potential Covid-19 vaccines are in various stages of development around the world, with shots developed in Russia and China already being deployed before full efficacy trials have been done, and front-runners from Pfizer PFE.N, Moderna MRNA.O and AstraZeneca AZN.L likely to have final-stage trial results before year-end.
Typically, the immunogenicity of potential vaccines is assessed in individual lab analyses, which aim to see whether biomarkers of immune response – such as antibodies and T-cell responses – are produced after clinical trial volunteers receive a dose, or doses, of the vaccine candidate.
But with more than 320 Covid-19 vaccine candidates in the works, Saville said, the many differences in data collection and evaluation methods are an issue.
As well as potential variations in markers of immunity, there are differences in how and where samples are collected, transported and stored – all of which can impact the quality and usefulness of the data produced, and make comparisons tricky.
And with a range of different vaccine technologies being explored – from viral vector vaccines to ones based on messenger RNA – standard evaluation of their true potential “becomes very complex”, she said.
“With hundreds of Covid-19 vaccines in development … it’s essential that we have a system that can reliably evaluate and compare the immune response of candidates currently undergoing testing,” she said.
By centralising the analysis in a lab network, much of what Saville called the “inter-laboratory variability” can be removed, allowing for head-to-head comparisons.
CEPI says all developers of potential Covid-19 vaccines can use the centralised lab network for free to assess their candidates against a common protocol. For now, the network will assess samples from early-stage vaccine candidate testing and first and second stage human trials, but CEPI said it hoped to expand its capacity to late stage (Phase III) trial data in the coming months.
Results produced by the network will be sent back to the developer, with neither CEPI nor the network owning the data.
CEPI itself is co-funding nine of the potential Covid-19 vaccines in development, including candidates from Moderna, AstraZeneca, Novavax NVAX.O and CureVac.
A major non-profit health emergencies group has set up a global laboratory network to assess data from potential Covid-19 vaccines, allowing scientists and drugmakers to compare them and speed up selection of the most effective shots, Reuters reported.
Speaking to Reuters ahead of announcing the
labs involved, Melanie Saville, director of vaccine R&D at the Coalition for Epidemic Preparedness Innovations (CEPI), said the idea was to “compare apples with apples” as drugmakers race to develop an effective shot to help control the Covid-19 pandemic.
The centralised network is the first of its kind to be set up in response to a pandemic, CEPI said in a media release.
The CEPI network will initially involve six labs, one each in Canada, Britain, Italy, the Netherlands, Bangladesh and India, Saville said.
The laboratories initially selected for this vaccine-assessment network are: Nexelis in Canada; Public Health England in the UK; VisMederi Srl in Italy; Viroclinics-DDL in the Netherlands; International Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b) in Bangladesh; and Translational Health Sciences and Technological Institute in India.
“Ensuring that immunological responses to Covid-19 vaccines are measured systematically in a manner that allows valid comparisons of vaccines will be essential to global efforts to identify those vaccines of greatest public health value,” said Professor John D Clemens, MD and Executive Director at icddr,b.
“We commend CEPI’s efforts to establish a centralised laboratory network, and, as an organisation with decades of experience in evaluating vaccines, we are keen to contribute to the network,” Prof Clemens added.
The network will use the same testing reagents-originating in the labs of Nexelis and PHE-and follow common protocols to measure the immunogenicity of multiple Covid-19 vaccine candidates including both CEPI-funded and non-CEPI funded developers, the CEPI release read.
This approach will ensure uniformity in assessment and informed identification of the most promising vaccine candidates, it also read, adding that CEPI is actively negotiating with additional laboratories to participate in this network.
In the network spanning Europe, Asia and North America, the labs will centralise analysis of samples from trials of Covid-19 candidates “as though vaccines are all being tested under one roof”, Saville said, aiming to minimise the risk of variation in results.
“When you start off (with developing potential new vaccines) especially with a new disease, everyone develops their own assays, they all use different protocols and different reagents – so while you get a readout, the ability to compare between different candidates is very difficult,” she told Reuters.
“By taking the centralised lab approach … it will give us a chance to really make sure we are comparing apples with apples.”
Hundreds of potential Covid-19 vaccines are in various stages of development around the world, with shots developed in Russia and China already being deployed before full efficacy trials have been done, and front-runners from Pfizer PFE.N, Moderna MRNA.O and AstraZeneca AZN.L likely to have final-stage trial results before year-end.
Typically, the immunogenicity of potential vaccines is assessed in individual lab analyses, which aim to see whether biomarkers of immune response – such as antibodies and T-cell responses – are produced after clinical trial volunteers receive a dose, or doses, of the vaccine candidate.
But with more than 320 Covid-19 vaccine candidates in the works, Saville said, the many differences in data collection and evaluation methods are an issue.
As well as potential variations in markers of immunity, there are differences in how and where samples are collected, transported and stored – all of which can impact the quality and usefulness of the data produced, and make comparisons tricky.
And with a range of different vaccine technologies being explored – from viral vector vaccines to ones based on messenger RNA – standard evaluation of their true potential “becomes very complex”, she said.
“With hundreds of Covid-19 vaccines in development … it’s essential that we have a system that can reliably evaluate and compare the immune response of candidates currently undergoing testing,” she said.
By centralising the analysis in a lab network, much of what Saville called the “inter-laboratory variability” can be removed, allowing for head-to-head comparisons.
CEPI says all developers of potential Covid-19 vaccines can use the centralised lab network for free to assess their candidates against a common protocol. For now, the network will assess samples from early-stage vaccine candidate testing and first and second stage human trials, but CEPI said it hoped to expand its capacity to late stage (Phase III) trial data in the coming months.
Results produced by the network will be sent back to the developer, with neither CEPI nor the network owning the data.
CEPI itself is co-funding nine of the potential Covid-19 vaccines in development, including candidates from Moderna, AstraZeneca, Novavax NVAX.O and CureVac.
